Drop vortex is utilized to convey sewage across elevation change in steep catchments. This structure is generally used when the elevation difference is more than 5 m. Since the air and water flow are extensively combined in these structures and the sewage flow might contain detergent and foam producing materials, foam could produce in some parts of drop vortex. This phenomenon could affect vortex airflow and reduce drop vortex hydraulic performance. In this investigation, the effects of Foam Producing Flow (FPF) on vortex air discharge were studied by a scaled model and statistical Design of Experiment (DoE) methodology. Effects of Concentration Number, detergent type, and Froude Number on the dependent variable, air discharge to water discharge ratio, were studied by 33 full-factorial design and 63 runs. Analysis of the results revealed that all design factors had meaningful effects on vortex air discharge and it decreases by the increase of Concentration and Froude Number. Moreover, it was illuminated that foam formation could boost air discharge by 82% and in some conditions could reduce it more than 64%.